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Journal article

Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC).

Abstract:

AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of four genes encoding AMPK (PRKAA1, PRKAA2, PRKAB1 and PRKAB2). Using a tagging appr...

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Publication status:
Published

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Publisher copy:
10.1007/s10549-010-1269-1

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Journal:
Breast cancer research and treatment
Volume:
127
Issue:
3
Pages:
761-767
Publication date:
2011-06-05
DOI:
EISSN:
1573-7217
ISSN:
0167-6806
URN:
uuid:6e3758fd-ad7c-466f-8350-3b14c7bcbae5
Source identifiers:
146768
Local pid:
pubs:146768

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