Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.

Journal article

Epithelial (E)-cadherin and its associated cytoplasmic proteins (alpha-, beta-, and gamma-catenins) are important mediators of epithelial cell-cell adhesion and intracellular signaling. Much evidence exists suggesting a tumor/invasion suppressor role for E-cadherin, and loss of expression, as well as mutations, has been described in a number of epithelial cancers. To investigate whether E-cadherin gene (CDH1) mutations occur in colorectal cancer, we screened 49 human colon carcinoma cell line...

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Authors: Efstathiou, J; Liu, D; Wheeler, J; Kim, H; Beck, N

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 96
• Issue: 5
• Pages: 2316-2321
• Publication date: 1999-03-01
• DOI: 10.1073/pnas.96.5.2316
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Animals; Polymorphism, Single-Stranded Conformational; Transfection; Humans; Growth Substances; Muscle Proteins; Mice; Neuropeptides; Cadherins; Point Mutation; Transplantation, Heterologous; Sequence Deletion; Colonic Neoplasms; Colorectal Neoplasms; Exons; Mice, Nude; Polymorphism, Genetic; Peptides; Mutation; Genetic Variation; Female; Frameshift Mutation; Introns; DNA Replication; Base Pairing; Cell Adhesion; Tumor Cells, Cultured; Recombinant Proteins; Mucins