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Understanding and modulating the MR1 metabolite antigen presentation pathway

Abstract:

The MHC class I-related protein, MR1, presents small metabolite antigens to an unusual subset of innate-like T cells. Herein, we highlight recent progress in our understanding of MR1’s unique antigen presenting pathway, with features of both MHC class I and class II antigen presentation, as highlighted during the EMBO Workshop: CD1-MR1, Beyond MHC-restricted lymphocytes, Oxford, 2019. There is increasing evidence for a role of MR1 restricted T cells in several immune contexts, from cancer to ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-4821-3801
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Name:
Medical Research Council
Grant:
4050630002
Publisher:
Elsevier
Journal:
Molecular Immunology More from this journal
Volume:
129
Pages:
121-126
Publication date:
2020-12-06
Acceptance date:
2020-11-24
DOI:
ISSN:
0161-5890
Language:
English
Keywords:
Pubs id:
1147877
Local pid:
pubs:1147877
Deposit date:
2020-12-04

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