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Functional analysis of the C. elegans cyld-1 gene reveals extensive similarity with its human homolog

Abstract:

The human cylindromatosis tumor suppressor (HsCyld) has attracted extensive attention due to its association with the development of multiple types of cancer. HsCyld encodes a deubiquitinating enzyme (HsCYLD) with a broad range of functions that include the regulation of several cell growth, differentiation and death pathways. HsCyld is an evolutionarily conserved gene. Homologs of HsCyld have been identified in simple model organisms such as Drosophila melanogaster and Caenorhabditis elegans...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-8418-9987
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
St Cross College
Role:
Author
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Role:
Author
ORCID:
0000-0002-5342-4873
Publisher:
Public Library of Science
Journal:
PloS ONE More from this journal
Volume:
13
Issue:
2
Article number:
e0191864
Publication date:
2018-02-02
Acceptance date:
2018-01-13
DOI:
ISSN:
1932-6203
Pmid:
29394249
Language:
English
Keywords:
Pubs id:
pubs:823275
UUID:
uuid:6e0b01d0-d605-4189-8f26-b354a179b30d
Local pid:
pubs:823275
Source identifiers:
823275
Deposit date:
2019-02-27

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