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Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes.

Abstract:

The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000. In 11 paired samples, serum levels were higher than (n = 10) or equal to (n = 1) cerebrospinal fluid levels; there was intrathecal synthesis of glycine receptor antibodies in each of the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awu142

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
137
Issue:
8
Pages:
2178-2192
Publication date:
2014-08-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Source identifiers:
470965

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