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Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets.

Abstract:

BACKGROUND: Blood flow is impaired in islet transplants, but there is conflicting evidence on improving the outcome by promoting vascularization. We previously reported that islet endothelial cells (EC) possess significant angiogenic capacity. METHODS: To further address this issue, we studied human islets in culture under hypoxic conditions. Moreover, we used a transgene mouse model with human vascular endothelial growth factor (VEGF) production in beta-cells under the control of the rat in...

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Authors


Schneider, D More by this author
Kidszun, A More by this author
Hauck-Schmalenberger, I More by this author
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Journal:
Transplantation
Volume:
79
Issue:
11
Pages:
1530-1536
Publication date:
2005-06-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:6e02499a-d70d-4464-a1dd-619e591456ad
Source identifiers:
266640
Local pid:
pubs:266640

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