- Abstract:
-
BACKGROUND: Blood flow is impaired in islet transplants, but there is conflicting evidence on improving the outcome by promoting vascularization. We previously reported that islet endothelial cells (EC) possess significant angiogenic capacity. METHODS: To further address this issue, we studied human islets in culture under hypoxic conditions. Moreover, we used a transgene mouse model with human vascular endothelial growth factor (VEGF) production in beta-cells under the control of the rat in...
Expand abstract - Publisher copy:
- 10.1097/01.tp.0000163506.40189.65
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- Journal:
- Transplantation
- Volume:
- 79
- Issue:
- 11
- Pages:
- 1530-1536
- Publication date:
- 2005-06-05
- DOI:
- EISSN:
-
1534-6080
- ISSN:
-
0041-1337
- URN:
-
uuid:6e02499a-d70d-4464-a1dd-619e591456ad
- Source identifiers:
-
266640
- Local pid:
- pubs:266640
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets.
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