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Journal article

Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma.

Abstract:

p27, cyclin D1, and retinoblastoma (Rb) protein have been demonstrated using immunohistochemistry in 189 cases of primary breast carcinoma with long-term follow-up. There was a statistically significant association between the expression of p27 and both cyclin D1 and the retinoblastoma gene product (pRb), corresponding to their close interactions in regulating the G1/S transition in the cell cycle. Low levels of p27 were seen in high-grade, rapidly proliferating, oestrogen receptor-negative t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Journal:
The Journal of pathology
Volume:
187
Issue:
2
Pages:
200-206
Publication date:
1999-01-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:6e016fd9-c5b8-4bc4-b536-f44dbd6d0aaa
Source identifiers:
83935
Local pid:
pubs:83935

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