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The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.

Abstract:

Group II metabotropic glutamate receptor agonists have been suggested as potential anti-psychotics, at least in part, based on the observation that the agonist LY354740 appeared to rescue the cognitive deficits caused by non-competitive N-methyl-d-aspartate receptor (NMDAR) antagonists, including spatial working memory deficits in rodents. Here, we tested the ability of LY354740 to rescue spatial working memory performance in mice that lack the GluA1 subunit of the AMPA glutamate receptor, en...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/ejn.13539

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Department:
Oxford, MSD, Experimental Psychology
More by this author
Department:
Oxford, MSD, Experimental Psychology
More by this author
Department:
Oxford, MSD, Experimental Psychology
More by this author
Department:
Oxford, MSD, Experimental Psychology
More by this author
Department:
Oxford, MSD, Experimental Psychology
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Contributors

Role:
Editor
Publisher:
Wiley Publisher's website
Journal:
European Journal of Neuroscience Journal website
Volume:
45
Issue:
7
Pages:
912-921
Publication date:
2017-03-04
Acceptance date:
2017-02-07
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Pubs id:
pubs:679803
URN:
uri:6dfed18a-313a-47bc-8ecf-8fec9e8fed89
UUID:
uuid:6dfed18a-313a-47bc-8ecf-8fec9e8fed89
Local pid:
pubs:679803
Language:
English
Keywords:

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