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Journal article

Effects of alteplase for acute stroke according to criteria defining the EU and US marketing authorizations: individual-patient-data meta-analysis of randomized trials

Abstract:

Background: The recommended maximum age and time window for intravenous alteplase treatment of acute ischemic stroke (AIS) each differ between Europe (EU) and United States (US).

Aims: To compare the effects of alteplase according to cohorts defined by current EU or US marketing approval labels, or by hypothetical revisions of the labels that would remove the EU upper age limit or extend the US treatment time window to 4.5 hours.

Methods: Individual-patient-data meta-analy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1177/1747493017744464

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Medical Research Council More from this funder
British Heart Foundation More from this funder
University of Glasgow More from this funder
University of Edinburgh More from this funder
Publisher:
SAGE Publications Publisher's website
Journal:
International Journal of Stroke Journal website
Volume:
13
Issue:
2
Pages:
175-189
Publication date:
2017-11-24
Acceptance date:
2017-10-01
DOI:
EISSN:
1747-4949
ISSN:
1747-4930
Source identifiers:
731600
Pubs id:
pubs:731600
UUID:
uuid:6dfe9693-b743-4616-a226-1aef55c5dd40
Local pid:
pubs:731600
Deposit date:
2017-10-02

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