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Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.

Abstract:

Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2 gene cause a monogenic speech and language disorder. Reduced functional dosage of the mouse version (Foxp2) causes deficient cortico-striatal synaptic plasticity and impairs motor-skill learning. Moreover, the songbird orthologue appears critically important for vocal learning. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1002145

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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Spiteri, E More by this author
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Institution:
University of Oxford
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Institution:
University of Oxford
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Funding agency for:
Vernes, SC
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Funding agency for:
Lockstone, HE
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Funding agency for:
Baban, D
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
7
Issue:
7
Pages:
Article: e1002145
Publication date:
2011-07-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:6dfc4adb-1078-401f-ad1b-2d1055b31a96
Source identifiers:
166453
Local pid:
pubs:166453

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