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Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.

Abstract:

Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2 gene cause a monogenic speech and language disorder. Reduced functional dosage of the mouse version (Foxp2) causes deficient cortico-striatal synaptic plasticity and impairs motor-skill learning. Moreover, the songbird orthologue appears critically important for vocal learning. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1002145

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Vernes, S
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Funding agency for:
Lockstone, H
Grant:
075491/Z/04
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Funding agency for:
Baban, D
Grant:
075491/Z/04
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
7
Issue:
7
Article number:
e1002145
Publication date:
2011-07-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
166453

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