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Vaccinia virus serpins B13R and B22R do not inhibit antigen presentation to class I-restricted cytotoxic T lymphocytes.

Abstract:

Vaccinia virus (VV) inhibits the presentation of certain epitopes from influenza virus nucleoprotein (NP), haemagglutinin (HA) and non-structural 1 (NS1) proteins to CD8+ cytotoxic T lymphocytes (CTL) by an unknown mechanism. We have investigated whether VV genes B13R and B22R, which encode proteins with amino acid similarity to serine protease inhibitors (serpins), are involved in this process. Recombinant VVs were constructed which express influenza virus proteins HA, NP or NS1 and which la...

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Publisher copy:
10.1099/0022-1317-76-9-2393

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Journal:
The Journal of general virology
Volume:
76 ( Pt 9)
Issue:
9
Pages:
2393-2398
Publication date:
1995-09-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:6decf70d-2f95-4850-9b61-88c6e66395f9
Source identifiers:
16717
Local pid:
pubs:16717

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