CD8 T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4 T Cells <200 Cell/μL: The DART Trial STI Substudy.

Journal article

Objective. To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed. Methods. CD8(+) T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial. Magnitudes, breadths, and functionality of IFN-γ and Perforin responses were compared in STI (n = 42) and continuous treatment (CT) (n = 46) before and after a single STI cycle when the DART STI trial was stopped ear...

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Authors: Serwanga, J; Mugaba, S; Betty, A; Pimego, E; Walker, A

• Publication status: Published
• Journal: AIDS research and treatment
• Volume: 2011
• Pages: 875028
• Publication date: 2011-01-18
• DOI: 10.1155/2011/875028
• EISSN: 2090-1259
• ISSN: 2090-1240
• Language: English