Targeting kinases for the treatment of inflammatory diseases.

Journal article

IMPORTANCE OF THE FIELD: Inflammatory diseases are one of the major health issues and have become a major focus in the pharmaceutical and biotech industries. To date, drugs prescribed for treatment of these diseases target enzymes that are not specific to the immune system resulting in adverse effects. The main challenge of this research field is, therefore, identifying targets that act specifically on the diseased tissue. AREAS COVERED IN THIS REVIEW: This review summarizes drug discovery ef...

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Authors: Müller, S; Knapp, S

• Publication status: Published
• Journal: Expert opinion on drug discovery
• Volume: 5
• Issue: 9
• Pages: 867-881
• Publication date: 2010-09-01
• DOI: 10.1517/17460441.2010.504203
• EISSN: 1746-045X
• ISSN: 1746-0441
• Language: English
• Keywords: mTOR; IKK; JAK3LCK; SYK; emerging targets; p38 alpha; inflammation; protein kinases