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Particle-based multiscale modeling of calcium puff dynamics

Abstract:

Intracellular calcium is regulated in part by the release of Ca2+ ions from the endoplasmic reticulum via inositol-4,5-triphosphate receptor (IP3R) channels (among other possibilities such as RyR and L-type calcium channels). The resulting dynamics are highly diverse, lead to local calcium “pu↵s” as well as global waves propagating through cells, as observed in Xenopus oocytes, neurons, and other cell types. Local fluctuations in the number of calcium ions play a crucial role in the onset of ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1137/15M1015030

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Name:
European Research Council
Grant:
FP7/2007-2013) Grant (239870
Publisher:
Society for Industrial and Applied Mathematics
Journal:
Multiscale Modeling and Simulation More from this journal
Publication date:
2016-07-21
Acceptance date:
2016-04-08
DOI:
EISSN:
1540-3467
ISSN:
1540-3459
Keywords:
Pubs id:
pubs:615195
UUID:
uuid:6de274c1-6843-46f7-8204-b19cfa72dbe9
Local pid:
pubs:615195
Source identifiers:
615195
Deposit date:
2016-04-14

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