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Journal article

Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains.

Abstract:

Maintaining homeostasis in higher organisms involves a complex interplay of multiple ubiquitous and organ-specific molecular mechanisms that can be characterized using functional genomics technologies such as transcriptomics, proteomics, and metabonomics and dissected out through genetic investigations in healthy and diseased individuals. We characterized the genomic, metabolic, and physiological divergence of several inbred rat strains--Brown Norway, Lewis, Wistar Kyoto, Fisher (F344)--frequ...

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Publication status:
Published

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Publisher copy:
10.1021/pr101000z

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Journal of proteome research More from this journal
Volume:
10
Issue:
4
Pages:
1675-1689
Publication date:
2011-04-01
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
Language:
English
Keywords:
Pubs id:
pubs:118070
UUID:
uuid:6de0a892-f591-49ee-a630-e5e630277026
Local pid:
pubs:118070
Source identifiers:
118070
Deposit date:
2012-12-19

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