Journal article
Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation.
- Abstract:
-
Aldose reductase (ALR2) has been the target of therapeutic intervention for over 40 years; first, for its role in long-term diabetic complications and more recently as a key mediator in inflammation and cancer. However, efforts to prepare small-molecule aldose reductase inhibitors (ARIs) have mostly yielded carboxylic acids with rather poor pharmacokinetics. To address this limitation, the 1-hydroxypyrazole moiety has been previously established as a bioisostere of acetic acid in a group of a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/j.ejmech.2017.02.053
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- European Journal of Medicinal Chemistry Journal website
- Volume:
- 130
- Pages:
- 328-335
- Publication date:
- 2017-02-24
- Acceptance date:
- 2017-02-20
- DOI:
- EISSN:
-
1768-3254
- ISSN:
-
0223-5234
- Pmid:
-
28259841
- Source identifiers:
-
684099
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:684099
- UUID:
-
uuid:6ddd830b-bd37-4426-b2a6-7f964bf98d92
- Local pid:
- pubs:684099
- Deposit date:
- 2017-06-13
Terms of use
- Copyright holder:
- Elsevier Masson SAS
- Copyright date:
- 2017
- Notes:
- © 2017 Elsevier Masson SAS. All rights reserved.
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