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Genomic variation and its impact on gene expression in Drosophila melanogaster

Abstract:

Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model organism populations are required. Here, we present a nucleotide resolution catalog of single-nucleotide, multi-nucleotide, and structural variants in 39 Drosophila melanogaster Genetic Reference Panel inbred lines. Using an integrative, local assembly-based approach for variant ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1003055

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Genetics More from this journal
Volume:
8
Issue:
11
Pages:
ARTN e1003055
Publication date:
2012-11-15
Acceptance date:
2012-09-13
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
UUID:
uuid:6ddcd07b-cf51-4c08-bac6-1e58f9967d92
Local pid:
pubs:365700
Source identifiers:
365700
Deposit date:
2013-11-16

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