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Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues

Abstract:
Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the tetrafluorinated ethylene group is compatible with O-phosphorylation of the primary alcohol, as demonstrated by the successful preparation of the tetrafluorinated naphthyl-C-nucleotide. © 2010 The Royal Society of Chemistry.

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Publisher copy:
10.1039/b922442d

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Journal:
Organic and Biomolecular Chemistry More from this journal
Volume:
8
Issue:
6
Pages:
1445-1454
Publication date:
2010-01-01
DOI:
ISSN:
1477-0520
Language:
English
Pubs id:
pubs:134400
UUID:
uuid:6ddb43cb-ddca-41f0-984e-89f340caa678
Local pid:
pubs:134400
Source identifiers:
134400
Deposit date:
2012-12-19

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