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Journal article

Galectin‐3 diminishes Wnt signaling in the postnatal subventricular zone

Abstract:

Postnatal subventricular zone (pSVZ) stem and progenitor cell proliferation is regulated by several developmental signaling pathways such as Wnt/β‐catenin. However, the molecular regulation of Wnt function in the pSVZ is poorly understood. We previously showed that Wnt signaling is upregulated in an SVZ gliomagenesis in vivo model. As well, the pro‐inflammatory molecule Galectin‐3 (Gal‐3) increases Wnt signaling in cancer cells and is expressed in the SVZ. Therefore, we asked if Gal‐3 has a s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/stem.3202

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-2931-0673
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/J018635/1
Publisher:
Wiley
Journal:
Stem Cells More from this journal
Volume:
38
Issue:
9
Pages:
1149-1158
Place of publication:
United States
Publication date:
2020-05-22
Acceptance date:
2020-04-23
DOI:
EISSN:
1549-4918
ISSN:
1066-5099
Pmid:
32442340
Language:
English
Keywords:
Pubs id:
1106434
Local pid:
pubs:1106434
Deposit date:
2020-06-11

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