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Journal article

Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding.

Abstract:

DRP-1 is a pro-apoptotic Ca2+/calmodulin (CaM)-regulated serine/threonine kinase, recently isolated as a novel member of the DAP-kinase family of proteins. It contains a short extra-catalytic tail required for homodimerization. Here we identify a novel regulatory mechanism that controls its pro-apoptotic functions. It comprises a single autophosphorylation event mapped to Ser308 within the CaM regulatory domain. A negative charge at this site reduces both the binding to CaM and the formation ...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/20.5.1099

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
EMBO journal More from this journal
Volume:
20
Issue:
5
Pages:
1099-1113
Publication date:
2001-03-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189

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