Journal article
Catalytic enantioselective synthesis of indanes by a cation-directed 5-endo-trig cyclization
- Abstract:
-
5-Endo-trig cyclizations are generally considered to be kinetically unfavourable, as described by Baldwin's rules. Consequently, observation of this mode of reaction under kinetic control is rare. This is usually ascribed to challenges in achieving appropriate approach trajectories for orbital overlap in the transition state. Here, we describe a highly enantio- and diastereoselective route to complex indanes bearing all-carbon quaternary stereogenic centres via a 5-endo-trig cyclization catal...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
European Research Council
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature chemistry Journal website
- Volume:
- 7
- Issue:
- 2
- Pages:
- 171-177
- Publication date:
- 2015-02-01
- DOI:
- EISSN:
-
1755-4349
- ISSN:
-
1755-4330
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:505137
- UUID:
-
uuid:6dc990a2-de90-4c26-aef9-50754bd116b6
- Local pid:
- pubs:505137
- Source identifiers:
-
505137
- Deposit date:
- 2016-02-03
Terms of use
- Copyright holder:
- Johnston et al
- Copyright date:
- 2015
- Notes:
- © 2015 Macmillan Publishers Limited. All rights reserved
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