Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma.

Journal article

Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher in patient than control sera (P = 0.009, 0.02 and 0.04 respectively). Moreover, high MIRN21 express...

Expand abstract

Authors: Lawrie, C; Gal, S; Dunlop, H; Pushkaran, B; Liggins, A

• Publication status: Published
• Journal: British journal of haematology
• Volume: 141
• Issue: 5
• Pages: 672-675
• Publication date: 2008-05-01
• DOI: 10.1111/j.1365-2141.2008.07077.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Retrospective Studies; Humans; Survival Analysis; Adult; Male; RNA, Neoplasm; MicroRNAs; Prognosis; Neoplasm Staging; Middle Aged; Female; Lymphoma, Large B-Cell, Diffuse; Tumor Markers, Biological