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RNA sequencing (RNA-Seq) reveals extremely low levels of reticulocyte-derived globin gene transcripts in peripheral blood from horses (Equus caballus) and cattle (Bos taurus)

Abstract:

RNA-seq has emerged as an important technology for measuring gene expression in peripheral blood samples collected from humans and other vertebrate species. In particular, transcriptomics analyses of whole blood can be used to study immunobiology and develop novel biomarkers of infectious disease. However, an obstacle to these methods in many mammalian species is the presence of reticulocyte-derived globin mRNAs in large quantities, which can complicate RNA-seq library sequencing and impede d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
Wellcome Trust
Grant:
097429/Z/11/Z
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Name:
Brazilian Science Without Borders—CAPES
Grant:
BEX-13070-13-4
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Name:
European Union
Grant:
Framework 7 Project Grant (No: KBBE-211602- MACROSYS
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Name:
Department of Agriculture, Food and the Marine
Grant:
Research Stimulus Grant (RSF 06 405
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Name:
Science Foundation Ireland
Grant:
SFI/15/IA/3154
Publisher:
Frontiers Media
Journal:
Frontiers in Genetics More from this journal
Volume:
9
Issue:
AUG
Article number:
278
Publication date:
2018-08-14
Acceptance date:
2018-07-09
DOI:
EISSN:
1664-8021
Pmid:
30154823
Language:
English
Keywords:
Pubs id:
pubs:911118
UUID:
uuid:6dc30b5e-d444-461c-89f1-cb41d3fe1e6c
Local pid:
pubs:911118
Source identifiers:
911118
Deposit date:
2018-11-12

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