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Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews

Abstract:

Background: Globally, sickle cell disease (SCD) is one of the commonest severe monogenic disorders, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD can cause severe pain, significant end‐organ damage, pulmonary complications, and premature death. Red blood cell (RBC) transfusions are used to treat complications of SCD, e.g. acute chest syndrome (ACS) (this often involves a single transfusion episode), or they can be part of a regular long‐term transfusion progra...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
ORCID:
0000-0002-6881-6984
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0003-4309-9162
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Name:
National Institute for Health Research
Publisher:
Wiley
Journal:
Cochrane Database of Systematic Reviews More from this journal
Volume:
2018
Issue:
8
Article number:
CD012082
Publication date:
2018-08-01
Acceptance date:
2018-07-31
DOI:
ISSN:
1469-493X
Pmid:
30067867
Language:
English
Pubs id:
pubs:896903
UUID:
uuid:6dc235b1-fb1e-4495-af9d-7eeb16a0362c
Local pid:
pubs:896903
Source identifiers:
896903
Deposit date:
2018-09-25

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