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Journal article

ST2 regulates allergic airway inflammation and T-cell polarization in epicutaneously sensitized mice.

Abstract:

IL-33 is an inducer of proinflammatory and T-helper type 2 (Th2) cytokines, which have an important role in atopic dermatitis (AD) and allergic asthma. ST2 is a specific receptor for IL-33 and is expressed on Th2 cells, eosinophils and mast cells. A murine model of AD was used to characterize the role of ST2 in allergen-induced skin inflammation and allergic asthma. ST2-/- and wild-type (WT) mice were epicutaneously sensitized with ovalbumin (OVA) and staphylococcal enterotoxin B, and intrana...

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Publisher copy:
10.1038/jid.2013.195

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Journal:
The Journal of investigative dermatology
Volume:
133
Issue:
11
Pages:
2522-2529
Publication date:
2013-11-05
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
URN:
uuid:6dbce09b-f82f-4e00-ab88-22830c83dd9e
Source identifiers:
402539
Local pid:
pubs:402539

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