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Pharmacoproteomic characterisation of human colon and rectal cancer

Abstract:

Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of > 10,000 proteins using mass spectrometry. Integration with proteomes of 90 CRC patients and matched transcriptomics data defined integrated CRC subtypes, highlighting cell lines representative of eac...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/msb.20177701

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
ORCID:
0000-0002-6651-1773
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Role:
Author
ORCID:
0000-0003-3904-5532
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Role:
Author
ORCID:
0000-0002-9224-3258
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Role:
Author
ORCID:
0000-0002-5433-2540
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Medical Research Council (MRC) More from this funder
Department of Oncology of the University of Oxford More from this funder
Scatcherd European Scholarship More from this funder
Publisher:
Wiley Open Access Publisher's website
Journal:
Molecular systems biology Journal website
Volume:
13
Issue:
11
Pages:
951
Publication date:
2017-11-03
DOI:
EISSN:
1744-4292
Pubs id:
pubs:745939
URN:
uri:6db32cfe-48c4-47f0-9f94-925d784ab335
UUID:
uuid:6db32cfe-48c4-47f0-9f94-925d784ab335
Local pid:
pubs:745939
Paper number:
ARTN 951

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