Ocular defects as surrogate end-points in trials comparing carotid endarterectomy and stenting.

Journal article

The effect of carotid endarterectomy (CEA) and carotid artery stenting (CAS) on visual function has not been a specific end-point of most trials comparing CAS and CEA. Ischaemic lesions of the retina and optic nerve have been reported to occur in 15-46% of carotid patients, while carotid artery stenosis significantly reduces blood flow to the eye and orbit, resulting in the ocular ischaemic syndrome.

Authors: Giannoukas, A; Paraskevas, K; Bulbulia, R; Halliday, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier Publisher's website
• Journal: European Journal of Vascular and Endovascular Surgery Journal website
• Volume: 48
• Issue: 1
• Pages: 105-106
• Publication date: 2014-04-01
• DOI: 10.1016/j.ejvs.2014.03.009
• EISSN: 1532-2165
• ISSN: 1078-5884
• Language: English
• Keywords: Angioplasty; Treatment Outcome; Endpoint Determination; Research Design; Vision Disorders; Clinical Trials as Topic; Humans; Carotid Artery Diseases; Intracranial Embolism; Endarterectomy, Carotid; Stents