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Journal article

Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats.

Abstract:

OBJECTIVE: To determine the effects of the angiotensin II receptor antagonist irbesartan, the calcium-channel blocker amlodipine, and hydrochlorothiazide/hydralazine on superoxide, NAD(P)H oxidase and nitric oxide bioavailability in spontaneously hypertensive stroke-prone rats (SHRSP). METHODS: Drugs or vehicle were administered for 8 weeks to SHRSP and blood pressure was measured weekly by tail-cuff plethysmography. After 8 weeks, superoxide levels in carotid arteries and aortas were measur...

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Publication status:
Published

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Authors


Brosnan, MJ More by this author
Hamilton, CA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Jardine, E More by this author
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Journal:
Journal of hypertension
Volume:
20
Issue:
2
Pages:
281-286
Publication date:
2002-02-05
DOI:
EISSN:
1473-5598
ISSN:
0263-6352
URN:
uuid:6d9ef648-55ce-41ed-8018-63802c65ff27
Source identifiers:
105168
Local pid:
pubs:105168

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