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Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials.

Abstract:

Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. We aimed to assess the effect of radiotherapy in these women after mastectomy and axillary dissection.We did a meta-analysis of individual data for 8135 women randomly assigned to treatment groups during 1964-86 in 22...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S0140-6736(14)60488-8

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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
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Cancer Research UK More from this funder
British Heart Foundation More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet (London, England) Journal website
Volume:
383
Issue:
9935
Pages:
2127-2135
Publication date:
2014-06-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:6d9697ef-2fa3-4b93-8725-1c2f188a3741
Source identifiers:
471188
Local pid:
pubs:471188

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