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Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer

Abstract:

Background: Germline mutations in the PALB2 gene are associated with the genetic disorder Fanconi anaemia and increased predisposition to cancer. Disease-associated variants are mainly protein-truncating mutations, whereas a few missense substitutions are reported to perturb its interaction with breast canc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.12688/wellcomeopenres.13113.1

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
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Funding agency for:
Butler, R
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Funding agency for:
Esashi, F
Publisher:
F1000Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
2
Issue:
110
Publication date:
2017-11-14
Acceptance date:
2017-11-10
DOI:
ISSN:
2398-502X
Pubs id:
pubs:744816
URN:
uri:6d8f1bd2-f59e-4429-9791-6f520e1937db
UUID:
uuid:6d8f1bd2-f59e-4429-9791-6f520e1937db
Local pid:
pubs:744816

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