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Journal article

Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts.

Abstract:

The effect of cis-diaminedichloroplatinum(II) (cisplatin) DNA damage on the repair of double-strand breaks by non-homologous end-joining (NHEJ) was determined using cell-free extracts. NHEJ was dramatically decreased when plasmid DNA was damaged to contain multiple types of DNA adducts, along the molecule and at the termini, by incubation of DNA with cisplatin; this was a cisplatin concentration-dependent effect. We investigated the effect a single GTG cisplatination site starting 10 bp from ...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gki528

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Nucleic acids research
Volume:
33
Issue:
8
Pages:
2531-2539
Publication date:
2005-01-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Source identifiers:
131009
Language:
English
Keywords:
Pubs id:
pubs:131009
UUID:
uuid:6d8d0d53-353c-42a6-83a8-fd51f4ec26f7
Local pid:
pubs:131009
Deposit date:
2012-12-19

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