Journal article
Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts.
- Abstract:
-
The effect of cis-diaminedichloroplatinum(II) (cisplatin) DNA damage on the repair of double-strand breaks by non-homologous end-joining (NHEJ) was determined using cell-free extracts. NHEJ was dramatically decreased when plasmid DNA was damaged to contain multiple types of DNA adducts, along the molecule and at the termini, by incubation of DNA with cisplatin; this was a cisplatin concentration-dependent effect. We investigated the effect a single GTG cisplatination site starting 10 bp from ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/nar/gki528
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Bibliographic Details
- Journal:
- Nucleic acids research
- Volume:
- 33
- Issue:
- 8
- Pages:
- 2531-2539
- Publication date:
- 2005-01-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:6d8d0d53-353c-42a6-83a8-fd51f4ec26f7
- Source identifiers:
-
131009
- Local pid:
- pubs:131009
Item Description
Terms of use
- Copyright date:
- 2005
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