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Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts.

Abstract:

The effect of cis-diaminedichloroplatinum(II) (cisplatin) DNA damage on the repair of double-strand breaks by non-homologous end-joining (NHEJ) was determined using cell-free extracts. NHEJ was dramatically decreased when plasmid DNA was damaged to contain multiple types of DNA adducts, along the molecule and at the termini, by incubation of DNA with cisplatin; this was a cisplatin concentration-dependent effect. We investigated the effect a single GTG cisplatination site starting 10 bp from ...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gki528

Authors


Diggle, CP More by this author
Bentley, J More by this author
Knowles, MA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Nucleic acids research
Volume:
33
Issue:
8
Pages:
2531-2539
Publication date:
2005
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:6d8d0d53-353c-42a6-83a8-fd51f4ec26f7
Source identifiers:
131009
Local pid:
pubs:131009

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