Journal article icon

Journal article

Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.

Abstract:
A review is given on some of the more recent knowledge of the enzymes involved in the control of glycosphingolipids biosynthesis and how catabolic deficiency leads to the glycosphingolipidoses. Focus is on how small-molecule inhibitors have been instrumental in probing the enzymes in these pathways and how their application has been taken from discovery in the laboratory to therapeutic use in man.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/cr990292q

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Publisher:
ACS
Journal:
Chemical reviews
Volume:
100
Issue:
12
Pages:
4683-4696
Publication date:
2000-12-05
DOI:
EISSN:
1520-6890
ISSN:
0009-2665
URN:
uuid:6d896866-4a0c-4fc5-855c-d5d9d140e392
Source identifiers:
100938
Local pid:
pubs:100938
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP