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Abnormalities in iNKT cells are associated with impaired ability of monocytes to produce IL-10 and suppress T-cell proliferation in sarcoidosis.

Abstract:

Sarcoidosis is a multisystem granulomatous disorder characterized by marked T-cell expansion of T helper 1 (Th1) cells. The cause of T-cell overactivity is unknown. We hypothesized that interleukin-10 (IL-10) production by a yet undefined cell type might be defective, resulting in loss of regulation of T-cell activity. Focusing on IL-10-producing monocytes, we first showed that monocytes isolated from the peripheral blood of corticosteroid-naïve sarcoidosis patients (n = 51) produced less IL-...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201344284

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Wiley
Journal:
European journal of immunology
Volume:
44
Issue:
7
Pages:
2165-2174
Publication date:
2014-07-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
462209
Language:
English
Keywords:
Pubs id:
pubs:462209
UUID:
uuid:6d85959d-5302-468b-b324-90430042b6c7
Local pid:
pubs:462209
Deposit date:
2014-06-16

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