Journal article
Abnormalities in iNKT cells are associated with impaired ability of monocytes to produce IL-10 and suppress T-cell proliferation in sarcoidosis.
- Abstract:
-
Sarcoidosis is a multisystem granulomatous disorder characterized by marked T-cell expansion of T helper 1 (Th1) cells. The cause of T-cell overactivity is unknown. We hypothesized that interleukin-10 (IL-10) production by a yet undefined cell type might be defective, resulting in loss of regulation of T-cell activity. Focusing on IL-10-producing monocytes, we first showed that monocytes isolated from the peripheral blood of corticosteroid-naïve sarcoidosis patients (n = 51) produced less IL-...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/eji.201344284
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Bibliographic Details
- Publisher:
- Wiley
- Journal:
- European journal of immunology
- Volume:
- 44
- Issue:
- 7
- Pages:
- 2165-2174
- Publication date:
- 2014-07-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
462209
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:462209
- UUID:
-
uuid:6d85959d-5302-468b-b324-90430042b6c7
- Local pid:
- pubs:462209
- Deposit date:
- 2014-06-16
Terms of use
- Copyright date:
- 2014
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