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Journal article

Migrating intestinal dendritic cells transport PrP(Sc) from the gut.

Abstract:

Bovine spongiform encephalopathy, variant Creutzfeldt-Jakob disease (vCJD) and possibly also sheep scrapie are orally acquired transmissible spongiform encephalopathies (TSEs). TSE agents usually replicate in lymphoid tissues before they spread into the central nervous system. In mouse TSE models PrP(c)-expressing follicular dendritic cells (FDCs) resident in lymphoid germinal centres are essential for replication, and in their absence neuroinvasion is impaired. Disease-associated forms of Pr...

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Publication status:
Published

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Authors


Farquhar, CF More by this author
Mabbott, NA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The Journal of general virology
Volume:
83
Issue:
Pt 1
Pages:
267-271
Publication date:
2002-01-05
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:6d831160-0092-4014-b10a-6508bb59aa63
Source identifiers:
30766
Local pid:
pubs:30766

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