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Journal article

Migrating intestinal dendritic cells transport PrP(Sc) from the gut.

Abstract:

Bovine spongiform encephalopathy, variant Creutzfeldt-Jakob disease (vCJD) and possibly also sheep scrapie are orally acquired transmissible spongiform encephalopathies (TSEs). TSE agents usually replicate in lymphoid tissues before they spread into the central nervous system. In mouse TSE models PrP(c)-expressing follicular dendritic cells (FDCs) resident in lymphoid germinal centres are essential for replication, and in their absence neuroinvasion is impaired. Disease-associated forms of Pr...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of general virology
Volume:
83
Issue:
Pt 1
Pages:
267-271
Publication date:
2002-01-01
EISSN:
1465-2099
ISSN:
0022-1317
Source identifiers:
30766
Language:
English
Keywords:
Pubs id:
pubs:30766
UUID:
uuid:6d831160-0092-4014-b10a-6508bb59aa63
Local pid:
pubs:30766
Deposit date:
2012-12-19

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