Journal article icon

Journal article

A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response

Abstract:

Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease expressed in microglia. There is, therefore, a need for authentic, efficient in vitro models to study human microglial pathological mechanisms. Microglia originate from the yolk sac as MYB-independent macrophages, migrating into the developing brain to complete differentiation. Here, we recapitulate microglial ontoge...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.stemcr.2017.05.017

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Haenseler, W
Grant:
Oxford pilot grant
More from this funder
Funding agency for:
Haenseler, W
Grant:
Oxford pilot grant
More from this funder
Funding agency for:
Cowley, S
Grant:
MC_PC_16034
More from this funder
Grant:
LC0910-004 (James Martin Stem Cell Facility Oxford, W.H., S.A.C.)
Expand funders...
Publisher:
Cell Press Publisher's website
Journal:
Stem Cell Reports Journal website
Volume:
8
Issue:
6
Pages:
1727-1742
Publication date:
2017-06-06
Acceptance date:
2017-05-15
DOI:
ISSN:
2213-6711
Source identifiers:
700430
Language:
English
Keywords:
Pubs id:
pubs:700430
UUID:
uuid:6d813413-994f-4a17-a2a4-2f68660f3bd7
Local pid:
pubs:700430
Deposit date:
2017-06-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP