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A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response

Abstract:

Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease expressed in microglia. There is, therefore, a need for authentic, efficient in vitro models to study human microglial pathological mechanisms. Microglia originate from the yolk sac as MYB-independent macrophages, migrating into the developing brain to complete differentiation. Here, we recapitulate microglial ontoge...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More from this funder
Name:
Royal Society
Funding agency for:
Newey, S
Grant:
Dorothy Hodgkin Fellowship
More from this funder
Name:
Arthritis Research UK
Funding agency for:
Haenseler, W
Grant:
Oxford pilot grant
More from this funder
Name:
Swiss National Foundation
Funding agency for:
Haenseler, W
Grant:
Oxford pilot grant
More from this funder
Name:
Medical Research Council
Funding agency for:
Haenseler, W
Cowley, S
Buchrieser, J
Cader, M
Wade-Martins, R
Grant:
Oxford pilot grant
MC_PC_16034
Momentum MC_PC_16034 (W.H., S.A.C., M.Z.C.) Awards
MC_PC_16034
MR/N013255/1
More from this funder
Name:
Oxford Martin School
Funding agency for:
Haenseler, W
Cowley, S
Grant:
Oxford pilot grant
LC0910-004 (James Martin Stem Cell Facility Oxford, W.H., S.A.C.)
MC_PC_16034
Publisher:
Cell Press
Journal:
Stem Cell Reports More from this journal
Volume:
8
Issue:
6
Pages:
1727-1742
Publication date:
2017-06-06
Acceptance date:
2017-05-15
DOI:
ISSN:
2213-6711
Language:
English
Keywords:
Pubs id:
pubs:700430
UUID:
uuid:6d813413-994f-4a17-a2a4-2f68660f3bd7
Local pid:
pubs:700430
Source identifiers:
700430
Deposit date:
2017-06-26

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