- Abstract:
-
In a study of 114 epidemiologically linked Zambian transmission pairs, we evaluated the impact of human leukocyte antigen class I (HLA-I)-associated amino acid polymorphisms, presumed to reflect cytotoxic T lymphocyte (CTL) escape in Gag and Nef of the virus transmitted from the chronically infected donor, on the plasma viral load (VL) in matched recipients 6 mo after infection. CTL escape mutations in Gag and Nef were seen in the donors, which were subsequently transmitted to recipients, lar...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.20072457
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 205
- Issue:
- 5
- Pages:
- 1009-1017
- Publication date:
- 2008-05-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:6d8132f1-8837-455d-a8d2-bfe8c0ce7f43
- Source identifiers:
-
191152
- Local pid:
- pubs:191152
- Copyright date:
- 2008
Journal article
Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.
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