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Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.

Abstract:

In a study of 114 epidemiologically linked Zambian transmission pairs, we evaluated the impact of human leukocyte antigen class I (HLA-I)-associated amino acid polymorphisms, presumed to reflect cytotoxic T lymphocyte (CTL) escape in Gag and Nef of the virus transmitted from the chronically infected donor, on the plasma viral load (VL) in matched recipients 6 mo after infection. CTL escape mutations in Gag and Nef were seen in the donors, which were subsequently transmitted to recipients, lar...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20072457

Authors


Goepfert, PA More by this author
Matthews, P More by this author
Prendergast, A More by this author
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Journal:
The Journal of experimental medicine
Volume:
205
Issue:
5
Pages:
1009-1017
Publication date:
2008-05-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:6d8132f1-8837-455d-a8d2-bfe8c0ce7f43
Source identifiers:
191152
Local pid:
pubs:191152

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