Immunity, safety and protection of an Adenovirus 5 prime--Modified Vaccinia virus Ankara boost subunit vaccine against Mycobacterium avium subspecies paratuberculosis infection in calves.

Journal article

Vaccination is the most cost effective control measure for Johne's disease caused by Mycobacterium avium subspecies paratuberculosis (MAP) but currently available whole cell killed formulations have limited efficacy and are incompatible with the diagnosis of bovine tuberculosis by tuberculin skin test. We have evaluated the utility of a viral delivery regimen of non-replicative human Adenovirus 5 and Modified Vaccinia virus Ankara recombinant for early entry MAP specific antigens (HAV) to sho...

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Authors: Bull, T; Vrettou, C; Linedale, R; McGuinnes, C; Strain, S

• Publication status: Published
• Journal: Veterinary research
• Volume: 45
• Pages: 112
• Publication date: 2014-01-01
• DOI: 10.1186/s13567-014-0112-9
• EISSN: 1297-9716
• ISSN: 0928-4249
• Language: English