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Thesis

Modelling and characterisation of in vivo human skin graft rejection for the investigation of regulatory T cell therapy in vascularised composite allotransplantation

Abstract:

Vascularised composite allograft (VCA) transplantation is revolutionising the field of plastic surgery. It reconstructs the most complex tissue defects effectively, achieving a new functional and cosmetic gold standard. However, VCA transplantation is currently limited by high rates of acute rejection and the need for patients without life-threatening conditions to be maintained on immunosuppression for life. Skin is the most problematic component of VCA transplants. It stimulates a vigoro...

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Institution:
University of Oxford
Research group:
Transplantation Research Immunology Group
Oxford college:
Balliol College
Department:
Medical Sciences Division - Surgery

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Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral

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