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Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth

Abstract:

We only have a rudimentary understanding of the molecular and cellular determinants of nerve regeneration and neuropathic pain in humans. This cohort study uses the most common entrapment neuropathy (carpal tunnel syndrome) as a human model system to prospectively evaluate the cellular and molecular correlates of neural regeneration and its relationship with clinical recovery. In 60 patients undergoing carpal tunnel surgery [36 female, mean age 62.5 (standard deviation 12.2) years], we used q...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/brain/awaa163

Authors


Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
143
Issue:
7
Pages:
2009–2026
Publication date:
2020-07-11
Acceptance date:
2020-04-02
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
1103901
Local pid:
pubs:1103901
Deposit date:
2020-05-11

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