Temporal changes in the messenger RNA levels of cellular immediate early genes and neurotransmitter/receptor genes in the rat neostriatum and substantia nigra after acute treatment with eticlopride, a dopamine D2 receptor antagonist.

Journal article

The cellular immediate early genes are involved in the transcriptional events associated with the dopaminergic regulation of neurotransmitter expression within neurons of the neostriatum. To characterize these events in detail, quantitative in situ hybridization histochemistry was used to assess the temporal effects of acute dopamine receptor blockade with eticlopride, a dopamine D2 receptor antagonist, on the messenger RNA expression of the immediate early genes and neurotransmitters/recepto...

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Authors: Sirinathsinghji, D; Schuligoi, R; Heavens, R; Dixon, A; Iversen, S

• Publication status: Published
• Journal: Neuroscience
• Volume: 62
• Issue: 2
• Pages: 407-423
• Publication date: 1994-09-01
• DOI: 10.1016/0306-4522(94)90376-x
• EISSN: 1873-7544
• ISSN: 0306-4522
• Language: English
• Keywords: Genes, Immediate-Early; Receptors, Neurotransmitter; Rats, Wistar; Early Growth Response Protein 1; Substantia Nigra; Oligonucleotide Probes; Immediate-Early Proteins; In Situ Hybridization; Kinetics; Rats; DNA-Binding Proteins; Animals; Transcription Factors; Neurotransmitter Agents; Genes, fos; Corpus Striatum; Time Factors; Autoradiography; Genes, jun; Sulfur Radioisotopes; Gene Expression; Zinc Fingers; Male; RNA, Messenger; Receptors, Dopamine D2; Salicylamides