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Dissociation of the human spliceosomal U1 snRNP complex

Abstract:

The non-covalent interactions which maintain protein-RNA complexes such as U1 snRNP in human spliceosome were investigated using nanoflow ESI-MS technique. The reconstituted U1 snRNP complex comprised core domain of Sm proteins and snRNA. The instrument pressure was varied by partial closure of rotary pump isolation valve and combination of cone, extractor and collision cell voltages were used to control extent of dissociation. The results show that when present in complex under similar instr...

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Pages:
403-404
Host title:
Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Publication date:
2002-01-01
Source identifiers:
323806
Pubs id:
pubs:323806
UUID:
uuid:6d655ca9-9d00-4efc-abfb-9708d03fad2b
Local pid:
pubs:323806
Deposit date:
2013-02-20

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