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Journal article

MHC-peptide-specific antibodies reveal inefficient presentation of an HLA-A*0201-restricted, Melan-A-derived peptide after active intracellular processing.

Abstract:

MHC-peptide-specific Fab antibodies binding to HLA-A*0201 complexes presenting the wild-type EAAGIGILTV (EAA) or analogue Melan-A 10-mer ELAGIGILTV (ELA) peptide were generated to study efficacy of peptide processing and presentation. None of the selected Fab antibodies detected the naturally processed EAA/HLA-A*0201 complex on melanoma tumor cells, confirming the known low peptide number on the cell surface. To study the effect of peptide presentation and processing in more detail, genes cod...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200636545

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
European journal of immunology More from this journal
Volume:
37
Issue:
7
Pages:
2008-2017
Publication date:
2007-07-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Language:
English
Keywords:
Pubs id:
pubs:33880
UUID:
uuid:6d62d071-6b8b-4110-97b1-a2c7d3e3d5ae
Local pid:
pubs:33880
Source identifiers:
33880
Deposit date:
2012-12-19

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