Journal article icon

Journal article

SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages

Abstract:

Phagocytosis is a pivotal process by which macrophages eliminate microorganisms after recognition by pathogen sensors. Here we unexpectedly found that the self ligand and cell surface receptor SLAM functioned not only as a costimulatory molecule but also as a microbial sensor that controlled the killing of Gram-negative bacteria by macrophages. SLAM regulated activity of the NADPH oxidase NOX2 complex and phagolysosomal maturation after entering the phagosome, following interaction with the b...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
  • (Accepted manuscript, pdf, 2.5MB)
Publisher copy:
10.1038/ni.1931

Authors


More from this funder
Name:
NIAID NIH HHS
Grant:
AI-15066
More from this funder
Name:
NIDDK NIH HHS
Grant:
P30 DK043351
Publisher:
Springer Nature
Journal:
Nature Immunology More from this journal
Publication date:
2010-09-05
Acceptance date:
2010-08-04
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Language:
English
Keywords:
Pubs id:
pubs:700170
UUID:
uuid:6d621d58-5d18-48d3-a958-c6d445ae22bf
Local pid:
pubs:700170
Source identifiers:
700170
Deposit date:
2017-06-12

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP