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Are experimental treatments for cancer in children superior to established treatments? Observational study of randomised controlled trials by the Children's Oncology Group.

Abstract:

OBJECTIVES: To assess how often new treatments for childhood cancer assessed in phase III randomised trials are superior or inferior to standard treatments and whether the pattern of successes and failures in new treatments is consistent with uncertainty being the ethical basis for enrolling patients in such trials. DESIGN: Observational study. SETTING: Phase III randomised controlled trials carried out under the aegis of the Children's Oncology Group between 1955 and 1997, regardless of whet...

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Publication status:
Published

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Publisher copy:
10.1136/bmj.38628.561123.7c

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Journal:
BMJ (Clinical research ed.)
Volume:
331
Issue:
7528
Pages:
1295
Publication date:
2005-12-01
DOI:
EISSN:
1756-1833
ISSN:
0959-8138
Source identifiers:
79379
Language:
English
Keywords:
Pubs id:
pubs:79379
UUID:
uuid:6d614ff1-2da5-4a11-bbe1-15b08050f0e1
Local pid:
pubs:79379
Deposit date:
2012-12-19

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