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Are experimental treatments for cancer in children superior to established treatments? Observational study of randomised controlled trials by the Children's Oncology Group.

Abstract:

OBJECTIVES: To assess how often new treatments for childhood cancer assessed in phase III randomised trials are superior or inferior to standard treatments and whether the pattern of successes and failures in new treatments is consistent with uncertainty being the ethical basis for enrolling patients in such trials. DESIGN: Observational study. SETTING: Phase III randomised controlled trials carried out under the aegis of the Children's Oncology Group between 1955 and 1997, regardless of whet...

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Publication status:
Published

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Publisher copy:
10.1136/bmj.38628.561123.7c

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
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Journal:
BMJ (Clinical research ed.)
Volume:
331
Issue:
7528
Pages:
1295
Publication date:
2005-12-05
DOI:
EISSN:
1756-1833
ISSN:
0959-8138
URN:
uuid:6d614ff1-2da5-4a11-bbe1-15b08050f0e1
Source identifiers:
79379
Local pid:
pubs:79379

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