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Associations of MC1R genotype and patient phenotypes with BRAF and NRAS mutations in melanoma

Abstract:

Associations of MC1R with BRAF mutations in melanoma have been inconsistent between studies. We sought to determine for 1,227 participants in the international population-based Genes, Environment, and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/NRAS subtypes. We used logistic regression adjusted by age, sex, and study design features and examined effect modifications. BRAF+ were associated with younger age, blond/light brown hair, increased nevi, and le...

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Publication status:
Published
Peer review status:
Peer reviewed

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Name:
National Institutes of Health
Grant:
P30 ES010126
Publisher:
Elsevier
Journal:
Journal of Investigative Dermatology More from this journal
Volume:
137
Issue:
12
Pages:
2588-2598
Publication date:
2017-08-24
Acceptance date:
2017-07-23
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
Pmid:
28842324
Language:
English
Pubs id:
pubs:724499
UUID:
uuid:6d590090-12bc-4eee-aa6b-7be64e128765
Local pid:
pubs:724499
Source identifiers:
724499
Deposit date:
2018-04-18

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