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Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice.

Abstract:

Inherited deficiency of early components of the classical complement pathway is strongly associated with the targeting of intracellular self Ags in systemic lupus erythematosus, but the reasons for this association are debated. In this study, we show that C1q deficiency increases the positive selection of B1b B cells and IgM autoantibodies by an intracellular self Ag, which is exposed on dying cells, and decreases the negative selection of autoreactive conventional B cells by the same Ag. The...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.178.5.2916

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Journal:
Journal of Immunology More from this journal
Volume:
178
Issue:
5
Pages:
2916-2922
Publication date:
2007-03-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:3554
UUID:
uuid:6d561093-3c29-40d6-8a84-34ff7bf27cdd
Local pid:
pubs:3554
Source identifiers:
3554
Deposit date:
2012-12-19

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