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The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.

Abstract:

BACKGROUND: The drug-metabolizing enzyme flavin-containing monooxygenase 2 (FMO2) is the predominant FMO isoform present in the lung of most mammals, including non-human primates. All Europeans and Asians tested have been shown to be homozygous for a non-functional variant, FMO2*2A, which contains a premature stop codon due to a single-nucleotide change in exon 9 (g.23238C>T). The ancestral allele, FMO2*1, encodes a functionally active protein and has been found in African-Americans (26%) ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Biotechnology and Biological Sciences Research Council More from this funder
Melford Charitable Trust More from this funder
Publisher:
Wolters Kluwer Publisher's website
Journal:
Pharmacogenetics and genomics Journal website
Volume:
18
Issue:
10
Pages:
877-886
Publication date:
2008-10-01
DOI:
EISSN:
1744-6880
ISSN:
1744-6872
Source identifiers:
259447
Language:
English
Keywords:
Pubs id:
pubs:259447
UUID:
uuid:6d52cc20-d594-4827-9c0b-d9dfda514d10
Local pid:
pubs:259447
Deposit date:
2013-11-17

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