Journal article
The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.
- Abstract:
-
BACKGROUND: The drug-metabolizing enzyme flavin-containing monooxygenase 2 (FMO2) is the predominant FMO isoform present in the lung of most mammals, including non-human primates. All Europeans and Asians tested have been shown to be homozygous for a non-functional variant, FMO2*2A, which contains a premature stop codon due to a single-nucleotide change in exon 9 (g.23238C>T). The ancestral allele, FMO2*1, encodes a functionally active protein and has been found in African-Americans (26%) ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1097/fpc.0b013e3283097311
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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Melford Charitable Trust
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Bibliographic Details
- Publisher:
- Wolters Kluwer Publisher's website
- Journal:
- Pharmacogenetics and genomics Journal website
- Volume:
- 18
- Issue:
- 10
- Pages:
- 877-886
- Publication date:
- 2008-10-01
- DOI:
- EISSN:
-
1744-6880
- ISSN:
-
1744-6872
- Source identifiers:
-
259447
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:259447
- UUID:
-
uuid:6d52cc20-d594-4827-9c0b-d9dfda514d10
- Local pid:
- pubs:259447
- Deposit date:
- 2013-11-17
Terms of use
- Copyright holder:
- Copyright © Lippincott Williams and Wilkins
- Copyright date:
- 2008
- Notes:
-
Copyright © Lippincott Williams and Wilkins. Unauthorized reproduction of this article is prohibited. The final version of this paper has been published in C
Pharmacogenetics and Genomics, Vol.18 No.10, October 2008, p 877-886.
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