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Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells.

Abstract:

How does cyclic AMP potentiate insulin secretion from pancreatic islet beta-cells? This question is fundamental to understanding how hormones such as glucagon, which elevates cAMP, stimulate insulin secretion and so contribute to the normal secretory response of the islet. It is well established that a rise in the cytoplasmic Ca2+ concentration ([Ca2+]i) is essential for insulin secretion and therefore cAMP has been proposed to act by elevating [Ca2+]i. But studies on permeabilized beta-cells...

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Publication status:
Published

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Publisher copy:
10.1038/363356a0

Authors


Ammälä, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Nature
Volume:
363
Issue:
6427
Pages:
356-358
Publication date:
1993-05-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:6d505fc4-e730-4798-bc85-4c5db439bf6c
Source identifiers:
26847
Local pid:
pubs:26847

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