Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.

Journal article

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

Authors: Allen, T; Jing, P; Calore, B; Horton, H; O'Connor, D

• Publication status: Published
• Journal: Journal of virology
• Volume: 76
• Issue: 20
• Pages: 10507-10511
• Publication date: 2002-10-01
• DOI: 10.1128/jvi.76.20.10507-10511.2002
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Macaca mulatta; Epitopes, T-Lymphocyte; CD4-Positive T-Lymphocytes; Simian immunodeficiency virus; Gene Products, gag; Cell Division; Immunodominant Epitopes; Vaccination; Histocompatibility Antigens Class I; Animals; T-Lymphocytes, Cytotoxic; Humans