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Combined medical therapy and carotid endarterectomy for asymptomatic stenosis: 10-year stroke prevention in ACST-1

Abstract:
In a randomised trial (ACST-1) of 3120 asymptomatic patients withsevere carotid narrowing comparing early with deferred carotid endarterectomy(CEA), CEA significantly reduced 10-year stroke risk. All other aspects ofpatient treatment were left to the discretion of the clinician. Throughout thetrial antithrombotic and antihypertensive drugs were widely used but use oflipid-lowering therapy increased substantially. We examined the influence ofdifferent medical treatments on the overall stroke prevention effect of the trial.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/bjs.7396

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Collaborators, ACST More by this author
Publisher:
Wiley Publisher's website
Volume:
98
Pages:
9-9
Publication date:
2010-12-23
DOI:
EISSN:
1365-2168
ISSN:
0007-1323
URN:
uuid:6d461643-1e9a-4dae-8935-75962f4ed200
Source identifiers:
252455
Local pid:
pubs:252455

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