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Combined medical therapy and carotid endarterectomy for asymptomatic stenosis: 10-year stroke prevention in ACST-1

Abstract:
In a randomised trial (ACST-1) of 3120 asymptomatic patients withsevere carotid narrowing comparing early with deferred carotid endarterectomy(CEA), CEA significantly reduced 10-year stroke risk. All other aspects ofpatient treatment were left to the discretion of the clinician. Throughout thetrial antithrombotic and antihypertensive drugs were widely used but use oflipid-lowering therapy increased substantially. We examined the influence ofdifferent medical treatments on the overall stroke prevention effect of the trial.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/bjs.7396

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
British Journal of Surgery Journal website
Volume:
98
Pages:
9-9
Host title:
VSGBI 2010: 45th annual scientific meeting of the Vascular Society of Great Britain and Ireland
Publication date:
2010-12-23
DOI:
EISSN:
1365-2168
ISSN:
0007-1323
Source identifiers:
252455
Pubs id:
pubs:252455
UUID:
uuid:6d461643-1e9a-4dae-8935-75962f4ed200
Local pid:
pubs:252455
Deposit date:
2012-12-19

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